Belgium – University of Antwerp Grant for PhD Student: Brain Hypoxia, Oxygen Sensing and the Role of Hemo-proteins
In the laboratorium for Protein Chemistry of the University of Antwerp is available a
Grant for a PhD Student (m/f)
Brain hypoxia, oxygen sensing and the role of hemo-proteins
After cardiovascular diseases and cancer, stroke and other hypoxia-related diseases are the third most common causes of death in many industrialised countries. In Europe, they represent the most important cause of morbidity and long-term disability imposing an enormous economic burden. The brains response to hypoxia and ischemia, which helps determine the clinical outcome, is a complex pattern of events including the synthesis of neuroprotective proteins. These proteins will help to counteract the adverse effects of hypoxia or ischemia by increasing anaerobic metabolism, tissue vascularity and O2 delivery or by the elimination of toxic compounds.
Neuroglobin and cytoglobin are recently discovered hemo-proteins involved in the protection of the cell against hypoxic/ischemic and oxidative/nitroso active stress. The mechanism of protection of the cell by hemo-proteins is unknown (Khan, A.A. et al. (2007) Proc Natl Acad Sci USA;104:19114-9; Brunori, M. and Vallone, B. (2007) Cell Mol Life Sci;64:1259-68; Pesce, A. et al. (2002) EMBO Rep.;3:1146-51).
We propose to unravel this mechanism by cell- and molecular biological methods (cell culture/transfection; transgenesis, micro-array and a proteomic approach).
Eligibility:
- Master in Science (Biology, Biochemistry, Bio-Engineer or Biomedical Sciences)
- Good study record and motivation.
- Protein chemical experience is an advantage.
Project type and duration:
Four year (UA-BOF).
Start date:
As soon as possible.
Contact:
Send detailed CV with names and addresses of two references to:
Prof. Luc Moens
Protein chemistry
Department of Biomedical Sciences
University of Antwerp
Universiteitsplein 1
B-2610 Antwerp
Belgium
Tel. +32 3 820 23 23
Fax. +32 3 820 22 48
email: luc.moens [at] ua.ac.be
website: http://www.ua.ac.be/english
Application deadline: 10 April 2008
The University of Antwerp is a knowledge centre with 3 400 employees which performs ground-breaking and innovative research of international standing. The university takes special care to ensure optimum support and supervision of students, and pays constant attention to educational innovation. The university is an autonomous pluralistic institution that is committed to the enhancement of an open, democratic and multicultural society, and it pursues an equal opportunities policy.
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